-Frank Bigelow (Edmond O'Brien), a certified public accountant, goes on vacation in San Francisco. Awakening after a night of drinking, Frank feels sick and is informed by a doctor that he is suffering from "iridium" poisoning and has only a few days to live.
-Determined to find his killer, and aided by his secretary and fiancé Paula (Pamela Britton), Frank traces a shipment of iridium which he notarized to Los Angeles. Arriving in Los Angeles, Frank finds the killers...
-Told entirely in flashbacks - with the unusual perspective of a murder victim functioning as his own detective, combined with the arbitrary nature of the motive and the circumstances leading to his poisoning - D.O.A. is an unusually cynical, memorable film.
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